DNA Bio-Computing

What's the DNA bio-computing

Background and Meaning

DNA bio-computing are emerging fields that are unlocking new possibilities in information technology, diagnostics and so on. These approaches use DNA molecules as a computing substrate or unit, offering nanoscale compactness and operation in unconventional media (including aqueous solutions, water-in-oil microemulsions and self-assembled membranized compartments) for applications beyond traditional silicon-based computing systems. To build a functional DNA computer that can process maybe even with store molecular information necessitates the continued development of strategies for data manipulation.

Some outstanding breakthroughs

A spatially localized architecture for fast and modular DNA computing (Nature nanotechnology 2017)

Utilizing spatial distribution to achieve the specific and modular transmission of information.

High-efficiency and integrable DNA arithmetic and logic system based on strand displacement synthesis (Nature Communications 2019)

Leveraging the DNA strand synthesis to utilize the logic gate

Molecular convolutional neural networks with DNA regulatory circuits (Nature Machine Intelligence 2022)

Using DNA strand displacement to accomplish the mimic of neruo network in traditional computers.

Some relative labs around the world

Tan lab-MBL-Aptamer

Hao Pei lab

Keith Pardee - PARDEE LAB

Natalio Krasnogor lab

Chunhai Fan lab