实验室简介
课题组以从事软凝聚态和生物物理的前沿交叉研究，致力于发展四维冷冻电子显微镜方法学 ，研究软物质动力学和非平衡统计物理生物学，及其在分子医学中的重大应用：
- （1）系统发展基于机器学习的蛋白质动力学重建和预测新方法，重点开发时间分辨冷冻电镜动力学重建方法，研究UPS蛋白质降解动态调控机制，研究UPS调控人类细胞中关键分子过程的结构、动力学和功能关系；
- （2）研究新型人工智能和动力学辅助药物发现和疫苗免疫原设计方法，集成超高分辨冷冻电镜方法，研发靶向UPS的新型化合物；
- （3）面向重大疾病和医疗健康需求，以调控UPS核心组分为主要干预手段，研发新型靶向分子胶技术和多特异性靶向降解疗法，为攻克神经退行疾病、癌症肿瘤和心脑血管疾病等提供临床候选原创新药分子。
Our research group is engaged in cutting-edge interdisciplinary research at the intersection of soft condensed matter and biophysics. We are committed to developing the methodology of four-dimensional cryo-electron microscopy, exploring the dynamics of soft matter, and studying non-equilibrium statistical biophysics. We also focus on the significant applications of these research areas in molecular medicine.
- (1) Systematically develop new methods for protein dynamics reconstruction and prediction based on machine learning, with a focus on developing time-resolved cryo-electron microscopy dynamics reconstruction methods. Investigate the dynamic regulatory mechanisms of UPS (Ubiquitin-Proteasome System) protein degradation and the structural, dynamic, and functional relationships of key molecular processes regulated by UPS in human cells.
- (2) Investigate novel artificial intelligence and kinetics-assisted methods for drug discovery and vaccine immunogen design, integrating ultra-high-resolution cryo-electron microscopy techniques to develop new compounds targeting the Ubiquitin-Proteasome System (UPS).
- (3) Aiming at major diseases and healthcare needs, and focusing on the core components of the Ubiquitin-Proteasome System (UPS) as the main intervention targets, we are committed to developing novel targeted molecular glue technologies and multi-specificity targeted degradation therapies. This research will provide original and clinically promising drug molecules for the treatment of neurodegenerative diseases, cancer, cardiovascular and cerebrovascular diseases, and other major illnesses.